Home Research Scientists
Researchers Overview

The Goodman Cancer Research Centre facilitates the support of outstanding and internationally recognized researchers at the forefront of research innovation. Research members of the Goodman Cancer Research Centre are comprised of two groups; full members and associate members.

Full members are appointed to various Departments across McGill University, including Biochemistry, Computer Science, Human Genetics, Medicine, Oncology, Physiology and Surgery.  

Likewise, associate members are appointed in various Departments and hospitals, including the Department of Anatomy and Cell Biology, Biochemistry, Biology, Human Genetics, Medicine, Microbiology and Immunology, Oncology, Pediatrics, Pharmacology and Therapeutics, the Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal Children's Research Institute, Montreal General Hospital, National Institute on Aging, St. Michael's Hospital, and the World Health Organization.

The Centre maintains very close bonds with the numerous departments and hospitals, these affiliations providing first-rate academic infrastructure required for the training and management of its students and researchers

All GCRC members have access to common areas, cutting edge equipment, core facilities and resources.

Full Members
• Associate Members


FULL MEMBERS

AREAS OF RESEARCH

Dr. Nicole Beauchemin

View Profile

Signal transduction. Functions of mouse CEACAM1 and role in tumor initiation and progression and in angiogenesis.

Dr. Maxime Bouchard

View Profile

Developmental Genetics of the urogenital system; mouse models of developmental diseases; organogenesis; urogenital cancer; cell signaling, transcriptional regulation.

Dr. Philip Branton

View Profile

Induction and suppression of apoptosis by human adenovirus proteins; regulation of cell proliferation by RB binding proteins.

Dr. Thomas Duchaine

View Profile


Gene regulatory functions and mechanisms of RNAi in development and treatment of cancer.

Link to the Duchaine Lab Website

Dr. A. Fuks

Dr. Imed Gallouzi

View Profile

mRNA metabolism during the cell cycle; cell differentiation.

Dr. Vincent Giguère

View Profile

Role of orphan nuclear receptors in metabolic control; vitamin A and estrogen signaling in breast cancer.

Dr. Philippe Gros
View Profile

Cancer resistance to chemotherapy and genetic models of innate resistance or susceptibility to disease.

Dr. Michael Hallett

View Profile


Breast Cancer, the Endoplasmic Reticulum interactome and trafficking diseases.
Link to website

Dr. Russell Jones

View Profile

Immunology and Cell Biology.

Dr. Luke McCaffrey
View Profile

Epithelial polarity and the regulation of mammary morphogenesis and breast cancer.

Dr. William Muller
View Profile

Tyrosine kinase epidermal growth factor receptor (EGFR) family.

Dr. Alain Nepveu
View Profile

Biological roles and molecular functions of the mammalian Cut homeodomain protein, CDP/Cux.

Dr. Morag Park
View Profile

Signal transduction pathways important for the development of human cancers and how they can be targeted with drug therapies.

Link to Lab Websitehttp://morag-park.lab.mcgill.ca

Dr. Arnim Pause
View Profile

Tumour suppressor genes and cancer metabolism

Dr. Jerry Pelletier
View Profile

Chemical biology approach to translation and transformation.

Dr. Julie St. Pierre
View Profile

Regulation of mitochondrial metabolism in physiological and pathophysiological conditions.

Dr. Gordon Shore
View Profile

Regulation of oncogene-induced apoptosis.

Dr. Peter Siegel
View Profile

Breast cancer metastasis to distinct organ sites (bone and liver).

Dr. Nahum Sonenberg
View Profile

Translational control mechanisms.

Dr. Jose Teodoro
View Profile

Tumour Angiogenesis and Apoptosis.

Dr. Michel Tremblay
View Profile

Role and function of tyrosine phosphatases, signal transduction, mouse genetics.

Dr. Yojiro Yamanaka
View Profile

Lineage specification and morphogenesis in early mouse development.

Dr. Xiang Jiao Yang
View Profile

Chromatin, transcription, cell signaling.

Dr. Maria Zannis-Hadjopoulos
View Profile

Mammalian origins of DNA replication, interacting sequence- and structure-specific proteins and role of cruciform structures in the initiation of mammalian DNA replication.

Dr. George Zogopoulos 

View Profile

Gastrointestinal cancer genetics

Website


ASSOCIATE MEMBERS

AREAS OF RESEARCH

Dr. Moulay Alaoui-Jamali 

View Profile

Cancer & Target Discovery; Screening for Novel Therapeutics.

Dr. Suhad Ali
View Profile

Signaling mechanisms elicited by the cytokine/hormone prolactin leading to cell proliferation, differentiation survival and carcinogenesis.

Dr. Gerald Batist
View profile

Molecular pharmacology of carcinogenesis and of chemotherapy resistance, and novel approaches to identify  modifiers of cellular detoxification pathways; lab-to-bedside studies of receptor  tyrosine kinase inhibitors in cancer therapy.

Dr. Pnina Brodt
View Profile

Molecular mechanisms of cancer metastasis, role of inflammation and the tumor microenvironment;  developing novel strategies for the prevention and treatment of  metastases.

Dr. Denis Cournoyer
View Profile

Gene therapy of cancer by hematopoietic chemoprotection, Gene therapy of inherited hematopoietic disorders by homologous recombination, and Gene   therapy of HIV disease.

Dr. David Dankort
View Profile

Identification of critical targets in lung cancer and melanoma progression and metastases.

Dr. Josée Dostie
View Profile

Spatial chromatin organization in the regulation of gene expression in mammalian cells.

Dr. Francois Fagotto
View Profile

1) Molecular and cellular basis of Wnt signal transduction.
2) Cellular mechanisms controlling cell mixing/cell sorting during formation of embryonic tissues.

Dr. Lorenzo Ferri
View Profile

The Role of Soluble L-selection in Altered Leukocyte Function in Sepsis Influence of Systemic Inflammation in Cancer Metastasis - TLR-4 Signaling in cancer cells - Neutrophil facilitated cancer progression.

Dr. Sidong Huang

View Profile

 Using functional genomic tools to study mechanisms of drug resistance and guide cancer therapy.

Dr. Nada Jabado
View Profile

Molecular profiling of paediatric gliomas. Creation of mouse models using targets involved in the formation and progression of paediatric gliomas.

Dr. Serge Jothy
View Profile

Renal pathology, cancer, tumor invasion, metastasis.

Dr. Antonis  Koromilas
View Profile

Control of protein synthesis, environmental stress, tumor suppressor genes, oncogenes, signal transduction, protein phosphorylation, breast cancer, chemotherapeutic drugs.

Dr. Nathalie Lamarche-Vane
View Profile

My laboratory investigates the molecular mechanisms regulated by the Rho family of GTPases, playing a crucial role in a plethora of cellular functions. In particular, we are interested to delineate the roles of Rho GTPases in cell motility and cell migration, such as axon guidance during the development of the nervous system or in cancer cell migration.

Dr. Pierre Laneuville
View Profile

Improving the prognosis of patients with leukemia and other diseases of the blood, genes responsible for leukemia, and stem and cord cell transplantation.

Dr. Paul Lasko
View Profile

Oogenesis and pole plasm assembly using the model organism Drosophila melanogaster.

Dr. Carmen Loiselle
View Profile

Differential cancer information-seeking behaviours, self-regulation, and psychosocial adjustment to cancer.

Dr. Koren K. Mann
View Profile

The health effects of environmental metal exposure including arsenic and tungsten.

Dr. Gregory Matlashewski
View Profile

Human papillomavirus, p53 and cervical cancer; human Leishmania infection.

Dr. Wilson Miller
View Profile

Molecular mechanisms underlying leukemia and breast cancer, with a focus on the development of novel targeted therapies.

Dr. Lawrence Panasci
View Profile

Alkylating agent chemotherapy resistance, improving the therapeutic index of anticancer drugs.

Dr. Michael Pollak
View Profile

Roles of peptide growth factors, particularly insulin-like growth factors (IGFs), in the pathophysiology of neoplasia.

Dr. Janusz Rak
View Profile

Tumor angiogenesis and anti-angiogenesis. The role of oncogenes in angiogenic and procoagulant events in cancer, particularly in pediatric patient population.  Age related changes in responsiveness/resistance to antiangiogenic agents.

Dr. Richard Roy
View Profile

Genetic approaches to understand the regulation of cell growth and proliferation in various developmental contexts.

Dr. Maya Saleh
View Profile

Molecular mechanisms and roles of innate immunity, inflammation and cell death in host defense, immune-mediated inflammatory diseases and cancer.

Dr. Uri Saragovi
View Profile

Structure-function relationships of macromolecules, particularly in receptor-ligand interactions, development of mimics of macromolecules including antibodies, cellular receptors, and polypeptide hormone ligands.

Dr. Cliff Stanners
View Profile

Molecular and Cellular Biology of Human Carcinoembryonic Antigen (CEA).

Dr. Moshe Szyf
View Profile

Epigenetics and the role of epigenetics in driving cancer and metastasis. Understanding the basic mechanisms of epigenetics and their aberration in cancer.  Identifying epigenetic targets for novel anticancer and antimetastatic agents.

Dr. Patricia Tonin
View Profile

Genetic factors implicated in the development and/or progression of human epithelial ovarian cancers, genetic factors that predispose to hereditary forms of breast and ovarian cancers.

Dr. Jackie Vogel
View Profile

Identification and characterization of proteins that promote proper chromosome segregation by linking the process of spindle assembly with DNA damage sensing and repair. 
Lab Website (Dept of Biology) School of Computer Science

Dr. Irving W. Wainer
View Profile

The development and application of novel bioanalytical methods to the etiology and diagnosis of diseases in the aging population and the optimization of treatment protocols for these diseases.

Website