Metabolomics is one of the emerging “omic” sciences in systems biology that include genomics, proteomics and transcriptomics, providing a greater holistic view of a system’s biological state. Metabolomics is the comprehensive analysis of metabolites (up to 1500da) that are either metabolic pathway intermediates or end points. An understanding of the biochemical changes in metabolism between healthy and disease states will potentially lead to better models for the disease progression, (dis)regulation, diagnosis, prognosis, treatment and response to treatment.
The Metabolomics Facility will offer:
• High throughput characterization of small molecules extracted from tissues, tissue culture, and biofluids (blood, serum, plasma, urine, etc)
• Pathway-targeted and un-targeted metabolite analysis
• Quantitative and qualitative analysis of metabolites.
Analytical technologies will include:
• Ultra high-pressure liquid chromatography coupled to mass spectrometry (UPLC/MS)
• High Resolution Nuclear Magnetic Resonance Spectroscopy
• High pressure liquid chromatography
This new facility is presently being developed as a result of a generous grant from the Canadian Foundation for Innovation and a donation from the Fraser Memorial Trust.