Mouse models of human disease are an invaluable research resource in the medical research community. In the Goodman Cancer Research Centre Mouse Transgenic Facility (GCRC-TG), we offer various services related to animal model generation and maintenance.
In operation since the early 1990s, originally under the direction of Dr. Michel Tremblay, the GCRC-TG facility has been providing high-quality services to researchers at McGill, in Montreal and across Canada, for over 20 years. Our unit is housed in a new, state of the art barrier facility at the GCRC. We have 5 microinjection stations, 2 animal rooms, a surgery room and cryopreservation room. The facility is staffed by personnel with over 10 years experience in the TG field and provides our expertise to support our scientific community. Since 2010 under the direction of Dr. Yojiro Yamanaka, we are constantly updating our methods and techniques and developing new technologies to respond various demands from our researchers.
List of services offered:
• Knockout/knockin mouse production - ES cell targeting 8 cell or blastocyst microinjection
• Transgenic mouse production - Pronuclear microinjection
• Embryo rederivation (cleaning of pathogen-infected mouse lines)
• Transgenic and knockout/in mouse breeding services
• Assisted reproduction
• Cryopreservation of mouse embryos and/or sperm