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Dr. Nahum Sonenberg
Thursday, 25 January 2007 16:43

 

Research

Dr. Sonenberg studies the molecular basis of the control of protein synthesis in eukaryotic cells and its importance in diseases such as cancer, obesity, diabetes and neurological diseases. His cancer related research program is as follows:

1)    Translational control of cancer: Regulation of translation in eukaryotes occurs primarily at the initiation step, mediated by eukaryotic Initiation Factors (eIFs). A key player is the mRNA 5’ cap-binding protein eIF4E, which is the limiting translation initiation factor in most cells, and whose forced excessive expression in mice causes cancer. eIF4E is elevated in several human cancers. Consistent with its critical role in cell growth, the amount of active eIF4E is regulated at several levels:

a) transcription
b) phosphorylation
c) binding to repressor proteins, the eIF4E-binding proteins (4E-BPs).

Dr. Sonenberg and his team discovered the function and control of the 4E-BPs by the signaling pathways involved in 4E-BP and eIF4E phosphorylation. They discovered that Ras signaling activates Mnk, which directly phosphorylates eIF4E on Ser209. In a recent discovery they showed that prevention of eIF4E phosphorylation reduces tumor growth. They are now collaborating with the pharmaceutical industry to discover drugs that inhibit eIF4E phosphorylation. 4E-BPs are phosphoproteins, and their phosphorylation status modulates their interaction with eIF4E. The PI3K/Akt/mTOR signaling pathway, whose components are mutated in many cancers, mediates 4E-BP phosphorylation and thus regulates translation.

2)    Viruses as anti-cancer drugs: building a safer and more selective oncolytic virus to treat cancer: Oncolytic viruses replicate better in cancer cells than in normal cells, destroying the tumors in which they replicate. A key discovery explaining the preferential replication of viruses in tumors was that cancer cells cannot respond well to the protein interferon, which is secreted by immune cells, and is the first defense mechanism of the organism against viral infections. One of the best-characterized oncolytic viruses is vesicular stomatitis virus (VSV), which does not normally infect humans. VSV propagates efficiently in tumors, unlike in normal cells. The differential VSV susceptibility of normal versus transformed cells is due to mutations in the interferon pathway.


The mammalian kinase target of rapamycin (mTOR) stimulates interferon production via phosphorylation of its effector proteins, 4E-BPs and S6Ks. Sonenberg’s group used this knowledge to employ a pharmacoviral approach to treat malignant gliomas (MGs). The highly specific inhibitor of mTOR rapamycin, in combination with VSV, dramatically increased the survival of immunocompetent rats bearing MGs. More importantly, VSV selectively killed tumor, but not normal cells, in MG-bearing rats treated with rapamycin. These results show that reducing tumor growth through inhibition of mTOR is an effective strategy to augment therapeutic activity in cancer.

3)    Mechanism of miRNA action in translation and mRNA decay: MicroRNAs are small non-coding RNAs (~21 nucleotides) that play an important role in gene regulatory networks in animals and plants. miRNAs play major roles in cancer development, progression and metastasis. It is estimated that ~70% of mammalian genes are regulated by miRNAs, but their mechanism of action is not well understood. Sonenberg et al developed in vitro systems from mouse cells that recapitulate the function of miRNAs in cells and showed that miRNAs inhibit initiation of mRNA translation and cause deadenylation of mRNAs. These new findings will help in understanding the role that miRNAs play in cancer development.

 

 

Dr. Sonenberg’s recent publications

Updated Jan 16, 2012

 
April 17, 2014

Dr. Julie St-Pierre Winner of the Maude Abbott Prize

The Goodman Cancer Research Centre (GCRC) is delighted to announce that Dr. Julie St. Pierre has won the 2014 Maude Abbott Prize, awarded by the Faculty of Medicine, McGill University.

Established in 2010, the Maude Abbott Prize recognizes outstanding female Faculty Members who excel in Education, Research or Administration with a focus at the early career stage.

The faculty, staff and trainees of the GCRC extend their heartfelt congratulations to Dr. St-Pierre for receiving this honour.

April 03, 2014

INVITED SEMINAR SPEAKER

Speaker: PIER PAOLO PANDOLFI, MD, PHD
Semiar Title:  Deconstructing the Genetics of Human Cancer and Its Therapeutic Implications
Seminar Date: Thursday, April 17th, 2014 | 12:00 NOON - 1:00 PM
Location: McIntyre Medical Building, Martin, Room 504
Link to abstract and more information

March 27, 2014

Defi Canderel 2013

May 8th, 2014 is the 25th Anniversary of Defi Canderel – Please help us raise funds for basic cancer research by supporting the GCRC Team -  http://deficanderel.com/participant/70183

Link to Poster

March 27, 2014

Young Woman in Bio

This year, the Goodman Cancer Research Centre paired up with the Young Woman in Bio – Greater Montreal Chapter to help introduce young girls to the importance of studying science.

On March 24, 2014 girls from Sacred Heart School of Montreal visited the Goodman Cancer Research Centre to learn about the important place women have in science, the basic cancer research done at the Centre, the many fascinating discoveries and, of course, the potential future careers. A dedicated group of graduate students took their time to meet with the students , show them research laboratories, and involved them in scientific experiments. Everyone had a blast. The day finished with a pizza lunch which provided an opportunity to answer many questions. Many thanks to our young scientists Alyssa (PhD), Juliana (PhD), Sylvia (MSc), Ruby (PhD), Laura (MSc) and Azadeh (RA) for being great mentors.

Link to Photos

March 14, 2014

DNA double-strand break formation and repair by homologous recombination in meiotic and mitotic cells

THE GOODMAN CANCER RESEARCH CENTER PRESENTS:

INVITED SEMINAR SPEAKER

Speaker: JEAN-YVES MASSON, PHD

Seminar Date: Wednesday, April 2nd, 2014 | 12:00 noon – 1:00 pm

Location: McIntyre Medical Building, Meakins Theatre, Room 521

View Poster

March 03, 2014

mTORC1 in cell growth and proliferation control

INVITED GUEST SPEAKER
Ken Noki, PHD, University of Michigan Medical School

Date: Wednesday, March 19th, 2014 - 12:00 noon

Location: McIntyre Medical Building, Martin Theatre, Room 504

Link to more Information

February 10, 2014

LA VIE EN ROSE DONATES $12,500 TO THE GCRC

The GCRC is very grateful to La Vie en Rose for its generous donation to basic cancer research.

La Vie en Rose, through its Roses of Hope Foundation, made 9 donations across Canada totalling $60,000 in time for World Cancer Day.

Link to the press release to read more

LA Vie en rose2014

February 05, 2014

INVITED SEMINAR SPEAKER: JOSEPH COSTELLO, PHD

Semiar Title:  Under pressure: the evolution of local tumor recurrence following therapy 

Seminar Date: Tuesday, February 11, 2014 | 10:00 AM - 11:00 AM

Location: McIntyre Medical Building, Meakins, Room 521

Link to abstract and more information

January 17, 2014

2014 Wolf Prize awarded to Dr. Nahum Sonenberg

It is with great honor and pride that the Goodman Cancer Research Centre recognizes an incredible achievement of one of our own scientists, Dr. Nahum Sonenberg, who is a co-recipient of the 2014 Wolf Prize in Medicine.

This prestigious award has been held by many renowned scientists, who have gone on to be recipients of the Nobel Prize.

Dr. Sonenberg shares the prize with two American Scientists for his seminal contributions to the field of mRNA translation, which has important implications for a variety of pathological conditions, including cancer. In fact, the biochemical pathways that have been worked out in Dr. Sonenberg’s laboratory have paved the way for numerous anti-cancer agents that are currently being developed for the management of this disease.

We extend our congratulations to Nahum on this well-deserved recognition.

For more information link to:

CBC News Article

Times of Israel Article

McGill Reporter Article

October 28, 2013

Dr. Michel L. Tremblay awarded the Prix Armand-Frappier 2013

We are proud to announce that Dr. Michel L. Tremblay has received the prestigious prix du Québec, Armand-Frappier award.

Each year, the government attributes five prix du Québec awards in the scientific field and six in the cultural field. The purpose of this tribute is to recognize the career of women and men who have demonstrated a passion for their calling. Individuals who have stood out by their creative or innovative spirit and whose work has contributed to the influence of Québec around the world and to the evolution of Québec society in their respective fields.

Please join us in congratulating our esteemed colleague for his outstanding achievements and its acknowledgement through the receipt of this award.

Michel continues to inspire and set an example of scientific excellence for all of us at the Goodman Cancer Research Centre.

October 28, 2013

Dr. Phil Gold: Recipient of the Prix Wilder Penfield for 2013

The Goodman Cancer Research Centre is enthusastic to announce that our founding director, Dr. Phil Gold, is the recipient of the Prix Wilder Penfield 2013.

Link to view video. Link to History of the GCRC.

September 16, 2013

Nahum Sonenberg was Awarded the Mclaughlin Medal from the Royal Society of Canada

We are proud to announce that The Royal Society of Canada has awarded the prestigious gold plated silver McLaughlin Medal to Dr. Sonenberg on September 6, 2013. The Royal Society of Canada is the senior national academy of distinguished Canadian scholars, artists and scientists. The McLaughlin Medal honors sustained excellence in medical science. We are delighted that Dr. Nahum Sonenberg’s work on the control of protein synthesis in cancer, autism, learning and memory and microRNA function has been awarded this prestigious honor. We extend our heartfelt Congratulations!

Link to Royal Society of Canada Medals and Awards.

September 16, 2013

Professor Moshe Szyf Named Fellow of the Royal Society of Canada

The Goodman Cancer Research Centre (GCRC) congratulates Dr. Szyf of the Department of Pharmacology and Therapeutics for being named Fellow of the Royal Society of Canada, honouring his groundbreaking contributions in the field of DNA methylation for the last three decades. He pioneered the idea that the chemical coating of DNA (DNA methylation) links experience “nurture” and our genes “nature”, building a bridge over the fissure between the social and biological sciences. Link to the Royal Society of Canada Class of 2013

September 05, 2013

Thesis Defense: Deciphering the regulation and role of protein tyrosine phosphatase 1B in prostate cancer

Date: Tuesday, September 10th 2013 at 9:00 AM

By: David Labbé, M.Sc., agr., chm.

Supervisor: Michel L. Tremblay, Ph.D., F.R.S.C.

Location: Rosalind and Morris Goodman Cancer Centre, Karp Conference Room (501)  Link to Thesis Defense Abstract

  David Labbé, GCRC

September 05, 2013

Workshop: How to Apply for a CIHR Fellowship

DATE: Wednesday 18th September 2013 TIME: 5:00 – 7:00 p.m.

Venue: Basement, Thomson House, McGill University, 3650 rue McTavish, Montreal.

The Association of Postdoctoral Fellows at McGill (APF) will be running a workshop on “How to Apply for a CIHR Fellowship” for Postdoctoral Fellows.

The event will feature two short presentations followed by questions and answers and an interactive discussion. The first speaker of the workshop, Dr. Madhukar Pai, from the Department of Epidemiology, Biostatics and Occupational Health at McGill University will give a 30 minute presentation on how to apply for a Postdoctoral Fellowship. Dr. Pai has served on the CIHR Post-PhD Fellowships committee and his presentation will be focused on putting together a strong CIHR Fellowship application. Following his presentation, there will be a 10 minute presentation from one of the awardees of the recent CIHR Fellowship competition. The rest of the workshop will consist of questions and answers between the audience, our guest speaker and four recent awardees of the CIHR Fellowship at McGill.

The workshop will provide a great opportunity for McGill postdocs to learn how to put a successful application for the upcoming CIHR fellowship competition in November 2013.

Finger food and non-alcoholic drinks will be provided.

Space is limited, so please register by sending an email to postdocs.mcgill@gmail.com with your Name, McGill ID number and Department.

We would like to thank the Faculty of Medicine for funding this event.

Regards,

The Association of Postdoctoral Fellows at McGill (APF)

September 04, 2013

GCRC RESEARCH DAY 2013

This year's GCRC Research Day will take place on Wednesday, November 20th. It is a student-led event showcasing the ongoing research projects undertaken by the members of McGill's Goodman Cancer Research Centre.
Link to more information. Registration is free but required. Lunch will be served. 

August 29, 2013

JOIN THE Goodman-Terry Fox run Sept 15

We have created a team, the "Goodman Foxtrotters", which will participate in the Terry Fox Run on Sunday, September 15th, 2013 in the Old Port. More info to follow re location.

The GCRC receives over $2,000,000 research funds from the Terry Fox Foundation each year. This pays students, postdocs and research staff as well as provides funds for research of more that half of the members of the GCRC. As you know raising funds as a charity in the present financial climate is very challenging.

WE NEED YOU TO PARTICIPATE – YOU CAN RUN, WALK, PUSH THE PUSHCHAIR SO WE HAVE NO EXCUSES!!.

It is really important that we get involved in this fundraising effort (especially those labs funded by the Terry Fox) and set the scene for future years. Please join the team and raise money. You can view our team page by clicking on the link below:

http://my.e2rm.com/TeamPage.aspx?langPref=en-CA&TSID=414370 From our team page, click on the ‘Join Team’ button to sign-up and help us fundraise.

If you can’t join us, you can also support our team by making a donation online using the link above.

Talk to your Pis !!!!

Thanks for your support!

Yours,

Morag

August 28, 2013

PROUD ANNOUNCEMENT - Samual Bronfman Medal Recipient

On behalf of the Goodman Cancer Research Centre, we are proud to announce Rosalind Goodman as the Samuel Bronfman Medal Recipient 2013.  This crowning award recognizes an extraordinary history of service and leadership contributing to the strength, vitality and continuity of the Montreal Jewish Community, and the people of the State of Israel.

 

Congratulations to our friend, Roz, on her many accomplishments dedicated to improving the lives of others in our community.


Dr. Morag Park

Director, Goodman Cancer Research Centre



RozGoodman.jpg

August 22, 2013

CONGRATULATIONS TO TWO FACULTY MEMBERS UPON RECEIVING TENURE

1. Dr. Jose Teodoro, whose research interest lies in identifying molecular pathways that limit tumour growth and delineating the mechanisms by which they become subverted in cancer. Visit Lab Website

2. Dr. Josée Dostie, whose goal is to understand the role of spatial chromatin organization in the regulation of gene expression in mammalian cells. Visit Lab Website

DrsDostieTeodoro

Please join us in congratulating each of these two exceptional professors for their consistent devotion to teaching, research, and service!

July 24, 2013

Just What the Doctor Ordered:

McGill University's exciting new cookbook for healthy living!

The Goodman Cancer Research Centre is enthusiastic to announce McGill's 1st edition illustrated cookbook of over 100 delicious and healthy recipes based on current scientific, nutritional research endorsed by the Faculty of Medicine and scientists of the Goodman Cancer Research Centre.


You are invited to contribute to this cookbook by becoming a sponsor and taking advantage of the many sponsorship benefits. 

Sponsorship Opportunities:  Click here for more information. 


Pre-orders of the cookbook are now available: Click here to order.

All proceeds from the sale of the cookbook will support cancer research at the GCRC.

June 05, 2013

Congratulations Jo-Ann Bader

It is a great pleasure to announce that Ms. Jo-Ann Bader has received the Dean of Medicine Awards of Excellence. These awards are conferred upon individuals for performance above and beyond the call of duty, dedication and caring, creative problem-solving, initiative, motivation and contribution to boosting morale. When asked to share what has motivated her during the past 42 years at McGill, she laughs as she quotes Confucius: “Choose a job you love, and you will never have to work a day in your life.”

<JBader2013

May 06, 2013

HOP into your favourite jeans on National Denim Day

On Tuesday, May 14th, hop into your favourite jeans and wear the CURE Foundation’s pink ribbon in support of National Denim Day, a fundraiser for breast cancer research.

Ribbons are available throughout campus. Link to CURE Collection Points where you can make your donation and pick up ribbons.

To obtain a tax receipt  for a donation of $20.00 or more, please complete this tax receipt form and attach it to your donation.

Link to more details about National Denim Day at McGill University

For more information, contact Louis Blais at louis.blais@mcgill.ca or by phone at  514-398-2595

Link to the Cure Foundation's Website

Enfiler vos jeans préférés pour la Journée Nationale du Denim

Mardi le 14 mai, enfilez vos jeans préférés et portez le ruban rose de la Fondation CURE en soutien à la Journée Nationale du Denim; une levée de fonds importante pour la recherche sur le cancer du sein.

Les rubans roses sont disponibles sur le campus. Voici la liste des endroits où vous pouvez faire votre don et obtenir des rubans CURE.

Pour obtenir un reçu d'impôt pour dons de 20,00 $ ou plus, veuillez remplir ce formulaire de reçu d’impôt et le joindre à votre don.

Pour obtenir plus de détails sur la Journée Nationale de Denim à l'Université McGill

Pour plus amples renseignements veuillez rejoindre Louis Blais à louis.blais@mcgill.ca ou par téléphone au 514-398-2595

Site web de la Fondation CURE 

April 29, 2013

MCGILL DANCES FOR CANCER RESEARCH' VIDEO has won The Michael E. DeBakey Journalism Award

We are very excited to announce that the McGill Dances for Cancer Research video has won another award - the Michael E. Debakey Journalism Award from the Foundation for Biomedical Research!!! Mrs. Goodman, Annette Novak, and their team will be receiving the award at a reception in Washington on May 14th.

The awards are presented for outstanding investigative or interpretive reporting published, broadcast or posted online.

Established in 1981, the Foundation for Biomedical Research is the USA's oldest and largest organization devoted to educating the public about how biomedical research leads to new medical advancements, treatments and cures for both humans and animals. Congratulations Mrs. Goodman, Annette Novak and all the participants of the video.

Link to McGill Dances for Cancer Research video.

April 24, 2013

Dr. Michel Tremblay receives the 2012 Robert L. Noble prize from the Canadian Cancer Society

Congratulations to Dr. Michel Tremblay for receiving the 2012 Robert L. Noble prize from the Canadian Cancer Society, which recognizes investigators for their outstanding achievements in Cancer Research. We also extend our congratulations to Dr. Michael Pollak, who has received the O. Harold Warwick Prize from the Canadian Cancer Society, which honours investigators whose research has impacted cancer control and treatment.

The Robert L. Noble Award is named after Dr Robert L. Noble, an outstanding Canadian investigator whose research led to the discovery of the widely used chemotherapeutic agent vincristine, and who served the former National Cancer Institute of Canada for many years in various capacities. Since 1993, the Canadian Cancer Society (CCS) has recognized outstanding Canadian cancer research by awarding three “CCS Awards for Excellence” to deserving Canadian researchers. This year, the Canadian Cancer Society will present the 2012 national Excellence Award to Dr. Michel Tremblay to honour him as an outstanding Canadian investigator whose contributions have led to significant advances in cancer research and cancer control, specifically in the field of protein tyrosine phosphatases.

Read the Canadian Cancer Society's announcement.

April 22, 2013

Commemorating the 60th anniversary of Stem Cell Renewal Theory

April 15, 2013

Montréal scientists identify a potential target to reduce the progression of metastases, the main cause of death for breast cancer patients

Dr. Jean-François Côté of the IRCM lead the team that collaborated in this study. We are proud to announce that among the noted researchers are  Morag Park and William J. Muller of the GCRC; and Mélanie Laurin, Benjamin Haibe-Kains (Director of the Bioinformatics and Computational Genomics research unit), Jennifer Huber, Ariane Pelletier and Tarek Houalla from the IRCM; and Yoshinori Fukui from the Medical Institute of Bioregulation at Kyushu University in Japan. The study is funded by the Canadian Cancer Society and the Fonds de recherché du Québec – Santé. 

Read the IRCM press release

March 06, 2013

Dr. Michel L. Tremblay receives CCS Innovation Award

We would like to congratulate Dr. Michel L. Tremblay on being awarded a Canadian Cancer Society Innovation grant entitled “Modulating T cell protein tyrosine phosphatase expression for T cell-based cancer immunotherapy”. These grants were created to support unique and creative research projects that will advance our understanding and ability to treat cancer. Read Canadian Cancer Society Press Release.

February 06, 2013

PubLIC FORUM CANCER: LOOKING FOR SIMPLICITY AND FINDING COMPLEXITY

Session 3: Having a Bone to Pick with Cancer 
Topic: Bone Cancer

Tuesday, April 30, 2013 | 6:30 - 8:30 p.m.

Martin Theatre, McIntyre Medical Sciences Building, 1200 Pine Ave West, Montreal, Qc H3A 1X1

Basic sciences, prevention and recent advances in treatment

REGISTRATION

INFORMATION ABOUT SPEAKERS AND TOPICS OF DISCUSSION

February 06, 2013

Canderel 2013

On Thursday, May 9, hundreds of runners will gather at the beautiful McGill University campus to warm up for the run of their lives. For 2 km through the seductive streets of downtown Montreal, runners from over 75 groups and corporations will show the city how we reach out, give back, and share. For more information and to register your team

link to the Canderel website  Link to GCRC Canderel Page  

February 06, 2013

MISAM 2013

MISAM 2013 on “Primary and Metastatic Brain Cancer: Molecular Pathways and Clinical Challenges” will take place at McGill University on June 12-14, 2013. Please visit the web site

November 29, 2012

MICRTP Workshop Intellectual Property Workshop

On November 27, 2012, the McGill Integrated Cancer Research Training Program (MICRTP) hosted an Intellectual Property workshop at the Goodman Cancer Research Centre. This workshop was designed to review the intellectual property (IP) concepts, review the roles of the Canadian government and McGill University in the IP process, present IP practices within the biomedical research sector, and discuss the career landscape in the IP filed. Over 30 participants from variety of McGill University departments were in attendance and the representatives of the Canadian government, McGill University and the private sector were on hand to talk about available resources and to answer questions. The meeting was made possible thanks to the input from the Graduate and Postdoctoral Studies Teaching and Learning Services at McGill University and the Canadian Intellectual Property Office (CIPO), an agency of Industry Canada. MICRTP wishes to thank Caroline Lefebvre from CIPO, Christian Cawthorn from Norton Rose, David Syncox and Michèle Beaulieu from McGill University and Michel Tremblay from GCRC who skillfully moderated the workshop.

November 29, 2012

Dr. Nahum Sonenberg receives the prestigious Senior International Research Scholar award

It is a great pleasure to congratulate Dr. Nahum Sonenberg for receiving the prestigious Senior International Research Scholar (SIRS) award from the Howard Hughes Medical Institute. 
The HHMI awards these grants to highly creative and accomplished scientists in the field of biomedical research. 
This award brings much deserved recognition to Dr. Sonenberg and is a great distinction not only for the Goodman Cancer Research Centre, but also to the entire McGill community. 

Link to HHMI announcement

October 26, 2012

Public Forum: Cervical and Ovarian Cancer

Date: November 12, 2012 Time: 6:30PM - 8:30PM  The GCRC hosted the Second Public Forum for it's 2012/2013 series.

If you missed the event, you are able to view it online. 

Link to Public Forum events

October 26, 2012

Congratulations to Dr. Michel Tremblay who was awarded the 2012 Prix Michel-Sarrazin

The GCRC is proud to congratulate Dr. Michel Tremblay who was awarded the 2012 Prix Michel-Sarrazin from the Club de Recherches Cliniques du Québec (CRCQ). This prize is in recognition of Dr. Tremblay's significant advancements in the field of science in Quebec.  Information regarding the prize Read about the Michael Sarrazin award

October 26, 2012

Public Forum: Cervical and Ovarian Cancer

Date: November 12, 2012 Time: 6:30PM - 8:30PM  The GCRC hosted the Second Public Forum for it's 2012/2013 series.

If you missed the event, you are able to view it online. 

Link to Public Forum events

October 26, 2012

MICRTP Workshop: Intellectual Property, the basics you need to know

Please reserve the date November 27, 2012; 1:00PM – 4:30PM; The McGill Integrated Cancer Research Training Program invites you to a workshop on “Intellectual Property: the basics you need to know”. The material covered will include: information on IP types; case study; guide to IP at McGill and careers in IP field.  The workshop will take place at the Goodman Cancer Research Centre. On line registration (mandatory) will be available as of November 1st, 2012; space limited.

September 12, 2012

Feldan HumanLike Research Platform Seminar

Date: Wednesday, September 19, 2012

Location: GCRC 5th Floor Atrium

Details

September 10, 2012

Internal Funding: Application Deadlines are approaching

Please be reminded that September 30th is the application deadline for Canderel and MICRTP Studentship and Fellowship awards.

As well, the Michael D’Avirro Studentship in Molecular Oncology Research and Innovative Awards.

Please visit the Internal Funding web page for application details.    Link

August 10, 2012

Seminar: Barcoded RNAi Screens Identify Novel Genes and Pathways Involved in the Carcinogenesis of Breast Cancer

Date: Tuesday, August 14, 11:00 am.

Speaker: Dr. Michael Boettcher 

See Poster

July 05, 2012

The McGill Dances for Cancer Research video has won a Bronze Medal for best use of social media.

We are proud to announce that the Council for Advancement and Support of Education has awarded the video McGill Dances for Cancer Research a bronze medal in the Circle of Excellence Awards for "best use of social media". This is a terrific achievement for all those who participated  on this project. Congratulations!

June 22, 2012

Natural Product Found in Sea Sponges Shows Promise in Preventing Cancer-Induced Muscle Wasting

The Goodman Cancer Research Centre is proud to congratulate Dr. Imed Gallouzi and his team for their groundbreaking discovery.

Link to Publication

The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice.
Di Marco S, Cammas A, Lian XJ, Kovacs EN, Ma JF, Hall DT, Mazroui R, Richardson J, Pelletier J, Gallouzi IE.
Nat Commun. 2012 Jun 12;3:896. doi: 10.1038/ncomms1899. PMID: 22692539 [PubMed - in process]

Read Canadian Cancer Society Press Reslease

June 09, 2012

Congratulations Sarah Assadian, Award winner of the Fonds Santé

The Goodman Cancer Research Centre is enthusastic to congratulate Sarah Assadian, PhD Student in Dr. Teodoro's Laboratory, for her award winning publication:

p53 Inhibits Angiogenesis by Inducing the Production of Arresten

Published in Cancer Research, 72(5), March 1, 2012, pages1270-1279. Link to More information

May 15, 2012

23rd Defi Canderel

The 23rd Défi Canderel fundraiser benefiting cancer research, held on May 4, 2012, was a tremendous success. View Poster

As many of you know, the Goodman Cancer Research Centre relies on the Défi Canderel’s continued support. Through studentships and fellowships made possible by the annual Défi fundraiser, we are better able to train the next generation of researchers that will tackle this disease.

Again this year, many Montreal business community’s representatives sent their teams to participate in this annual “fun run” in support of cancer research pursued at the Goodman Cancer Research Centre and Institut du cancer de Montréal. As the crowds gathered in anticipation of the race, we were proud to see them, for the first time this year, at McGill’s Roddick Gates.

We are also extremely proud of our GCRC running team, composed of graduate students, post-doctoral fellows and research staff, which represented the Centre at the fundraiser. Through their efforts and team spirit, they were able to raise $3,151.00 for Défi Canderel.In addition, many volunteers from GCRC generously dedicated their time before and during the race to ensure its success. I want to thank all those involved, the runners and volunteers, for their efforts and enthusiasm.

All of you have set the bar higher for next year, and for that we are grateful!

Peter Siegel

Interim Director, Goodman Cancer Research Centre

April 23, 2012

Breast cancer research at McGill could make mammography obsolete

Antibody colocalization microarray: a scalable technology for multiplex protein analysis in complex samples.

Pla-Roca M, Leulmi RF, Tourekhanova S, Bergeron S, Laforte V, Moreau E, Gosline SJ,

Bertos N, Hallett MPark M, Juncker D.

Mol Cell Proteomics. 2012 Apr;11(4):M111.011460. Epub 2011 Dec 14

Read Report from Science Daily     Read report from MCPONLINE

Read Gazette Article                          Read Gazette Article 2   

More links on the Juncker lab web page

April 11, 2012

Public Forum Session 4

Melanoma: Making a Mountain out of a Mole?

Date: April 24, 2012 Time: 6:30 pm - 8:30 pm

Location: Martin Amphitheatre, 6th floor, McIntyre Medical Sciences Building

With summer just around the corner, now is the time to learn how to care for your skin while having fun in the sun.  

A panel of experts, will include Nicole Beauchemin, Ph. D., Henry R. Shibata, M.D., M. Sc., FACS, FRCSC, Beatrice Wang, M.D., C.M., FRCP, CSPQ, FAAD, Francine Tremblay, M.D., FRSC(C), and David Dankort, Ph. D., will discuss cutting-edge research on melanoma, early diagnosis, prevention, surgical intervention and new advances in medical and targeted therapies.
 
If you wear your skin proud, you will hurry to register at annette.novak@mcill.ca. Seating is limited.

More Information

Registration:  Online or contact annette.novak@mcgill.ca

See Poster


    

March 16, 2012

23rd Defi Canderel 2012

Date: Friday May 4th, 2012 at 11:00 AM

Click here for Information about Defi Canderel  View Poster

It is this time of the year again when we are getting ready to participate in the Annual Defi Canderel. We are looking for a team of volunteers and a team of runners to represent GCRC on May 4th.

Runners: Dmitri Kharitidi has volunteered again to look after the organization of the runners team. Thus, if you wish to run in the Defi Canderel Race please send a quick email to Dmitri (dmitri.kharitidi@mail.mcgill.ca) to indicate your willingness to run. Also, since we are looking into providing GCRC T-shirts to all the runners, we will need the size of the T-shirt for you. Most importantly and drawing on success of the previous year, I would like to challenge each runner to fundraise for this run. The aim this year is to collect $2,500 from our team (last year we brought over $ 1,600). At the end of the run the person who raised the most money will receive a prize.

Volunteers: Leah Donnelly (leah.donnelly@mcgill.ca) will help coordinate the team of volunteers. Please send her your availability. There will be a meeting scheduled during the week of April 16, 2012 where the volunteer tasks will be discussed. We will send you more details once the group of dedicated volunteers is identified. Please keep in mind that if you can’t participate on the day of, we can find few tasks you can help us with before the run.

On behalf of GCRC administration I would like to thank all of those who will participate this year. I am looking forward to working with you again this year.

Dr. Magdalena Maslowska

Research Advisor

McGill University

Goodman Cancer Research Centre

3655 Promenade Sir-William-Osler,

Room 702A Montreal, QC, H3G 1Y6

Tel.: 514-398-6268

 Fax: 514-398-6769

January 30, 2012

Top Story from Cancer Research

PTP1B Is an Androgen Receptor-Regulated Phosphatase that Promotes the Progression of Prostate Cancer

In this study, Drs. Michel Tremblay, Vincent Giguere and their team of researchers found that the protein tyrosine phosphatase PTP1B, a well-established regulator of metabolic signaling, was induced after androgen stimulation of androgen receptor-expressing prostate cancer cells. [Cancer Res]

Abstract

More Goodman Scientific Publications

January 25, 2012

The McGill Dances for Cancer Research video lives and breathes a life of its own on-line

This is a link to a news article the Toronto Star. Please note the interviews with Dr. Phil Gold and Dr. Nahum Sonenberg in the article.

January 05, 2012

Seminar Series/ Workshops/ Product Shows

Seminar Series:  (see complete schedule)

 May 2nd, 2012Brad St. Croix, Ph.D.  See Poster

WIP (see complete schedule)

April 3rd, 2012: Harvey Smith
Title: "Functions of C-Src In Erbb2-Driven Breast Cancer"

January 04, 2012

Dr. Peter Siegel Appointed Associate Director

We are pleased to announce that Dr. Peter Siegel has accepted the position of  Associate Director of the Goodman Cancer Research Centre. Dr. Siegel  joined the GCRC as an Associate Member in 2007, and became a Full Member in 2009.  Since 2009, he has been involved in most of the Centre’s major scientific and operational activities.

Dr. Siegel, an authority in the field of  breast cancer metastasis, brings a wealth of scientific and collegial experience to his new role and we are delighted that he is now part of  the administrative team.

Please join us in congratulating Dr. Siegel on this new position and in wishing him continued success.

January 04, 2012

Product Shows

Jan 30 - Feb 3, 2012 8am - 4:30pm Mettler Toledo & Rainin: Pipette Service Clinic  Poster

Jan 31, 2012 10 am - 4 pm FroggaBio demo  Poster

Feb. 1, 2012 10am - 2pm  Medicom & AMD Ritmed Product show will be held in the atrium   Poster

Feb 15, 2012 9 am - noon EMD Millipore Product Show Poster

December 12, 2011

Dr. Branton receives Exceptional Leadership in Cancer Research

Dr. Philip E. Branton receives the award for Exceptional Leadership in Cancer Research for his outstanding contributions to the development of the cancer research community and inter-agency research collaboration in Canada through the founding of the Canadian Cancer Research Alliance.

December 03, 2011

New Discovery from GCRC

Dr. William J. Muller and his laboratory recently discovered a new important therapeutic target in breast cancer. The study was published online in Cancer Discovery. >> see more details of the study

>> see original paper

December 03, 2011

Upcoming Seminars

Tuesday, December 13, 2011 / 12:00 - 13:00 - Work In Progress

"Defining the role of KRAS-activated pathways in lung cancer" Karp Conference Room 501, Goodman Cancer Research Centre, Dr. Guillaume Vandal


Tuesday, December 6, 2011 / 12:00 - 13:00 - Work In Progress

"Characterization of GPNMB-induced Breast Cancer Invasion, Metastasis and Tumor Formation" Karp Conference Room 501, Goodman Cancer Research Centre, Dr. Gordana Maric

December 03, 2011

"Outstanding Volunteer of the Year" Award

We are most pleased to announce that Mrs Rosalind Goodman received the "Outstanding Volunteer of the Year" award for 2011 from The Association of Fundraising Professionals, Quebec Chapter .

November 30, 2011

Seminars 2011

Tuesday, November 29, 2011 / 12:00 - 13:00 - Work In Progress

 "Prognostic Prediction in Breast Cancer" Karp Conference Room 501, Goodman Cancer Research Centre, Dr. Ali Tofigh


Thursday, November 24, 2011 / 11:00AM - 12:00PM

"Functions of Platelets in Inflammatory Arthritis" Lyman Duff Building, Room 507/509, 3755 University Street, 5th floor, Dr. Eric Boilard, Assistant Professeur, Centre du Recherche du CHUL, Université Laval


Wednesday, November 23, 2011

"Tumor suppression by the retinoblastoma gene in the absence of E2F transcriptional repression"

McIntyre Medical Sciences Building, Meakins, Rm 521  

Fred Dick, PhD

Associate Professor, Department of Biochemistry, University of Western Ontario;
Scientist, London Regional Cancer Program, Cancer Research Labs

>> See the poster in PDF

November 23, 2011

News & Announcements

Congratulations to Dr. William J. Muller, he was just elected as a new Fellow to the Royal Society of Canada .(10-Nov)

TERRY FOX FOUNDATION GIVES $12.7M TO RESEARCH CENTRES Some $3.8 million will be given to Goodman Cancer Research Centre for a three-year program to study molecular links between obesity, diabetes and cardiovascular diseases and cancer. See details...

Congratulations to Dr. Nahum Sonenberg, he's been awarded the Lewis Rosentiel Award.  He will be receiving $30,000 and a medal for his accomplishment at Brandeis University in MA.